AI-Based Discovery and CryoEM Structural Elucidation of a KATP Channel Pharmacochaperone
Pancreatic β-cells secret insulin in response to an increase in blood glucose levels to maintain glucose homeostasis. Central to this process is the ATP-sensitive potassium (KATP) channel assembled from four pore-forming Kir6.2 subunits (encoded by KCNJ11) …